Sample syllabus: GCD 4134
Spring 2007
Class meets: Monday/Wednesday 9:05-10:20 AM
Amundson Hall R. 240, Minneapolis Campus
Instructor: Dr. Victoria Iwanij
Office: MCB 5-136
Telephone: 624-4942
e-mail: iwani001@umn.edu
About the course:
The course will cover major subjects of modern Endocrinology; Structure, organization and function of endocrine glands, properties of major groups of hormones, mechanism of hormone action and structure of receptor molecules, biosynthesis, storage, and deactivation of hormones, regulation and control of hormone secretion, regulation of metabolism, homeostasis, and feed-back mechanisms.
We will use “Essential Endocrinology and Diabetes” 5th edition by Richard IG Holt and Neil A Hanley, Blackwell Publishing as a basic text as and 3-4 supplementary articles for the background reading. Additional resources useful for this class include: “Endocrinology” 5th edition by Mac Hadley; “Williams Textbook of Endocrinology” Wilson, J.D. editor, “Molecular Cell Biology” 4th or 5th edition, Lodish et al., and The Oxford Dictionary of Biochemistry and Molecular Biology that should ease wading through most of technical terms used in the textbooks or scientific articles.
Exams:
There will be two midterm exams and final exam, all in class written exams combination of multiple choice and short answer format. A study guide will be provided before exams.
Office hours:
Immediately after class till 11 AM, or by appointment.
| Date | Topic |
|---|---|
| Jan. 17 | Course organization, Introduction to and survey of endocrine tissues, experimental approach in endocrinology (Chapter 1 and 3) |
| Jan. 22 | Mechanisms of hormone action, Cell receptors, second messengers, stimulus response coupling, termination of hormone action. (Chapter 3) |
| Jan. 24 | Hypothalamohypophyseal complex / Neuroendocrinology (Chapter 5) |
| Jan. 29 | Neurohypophysis: Biosynthesis and secretion of hormones (Chapter 5) |
| Jan. 31 | Neurohypophysis: Hormones and their actions (Chapter 5) |
| Feb. 5 | Adenohypophysis: Cells, hormones, regulation of secretion, releasing factors (Chapter 5) |
| Feb. 7 | Adenohypophysis: Hormones and their actions (Chapter 5) |
| Feb. 12 | Hormones of growth; GH, somatomedins, (Chapter 5) |
| Feb. 14 | Thyroid gland: Structure and function. (Chapter 8) |
| Feb. 19 | First Examination (Subjects including Feb. 12th lecture) |
| Feb. 21 | Thyroxin: regulator of growth and differentiation (Chapter 8) |
| Feb. 26 | Hormones of calcium homeostasis (Chapter 9) |
| Feb. 28 | Control of Calcium homeostasis (Chapter 9) |
| March 5 | Hormones of digestion and assimilation(Chapter posted on e-reserves) |
| March 7 | Endocrine pancreas: Structure and functionof Islets of Langerhans. (Chapter 11) |
| March 12-16 | Break |
| March 19 | Mechanism of insulin action, insulin receptors, down-stream signaling.(Chapter 11) |
| March 21 | Metabolic homeostasis, insulin and glucagon, diabetes.(Chapter 11 and 12) |
| March 26 | Adrenal gland; organization and cell types, Adrenal medulla: Synthesis and metabolism of catecholamines. (Chapter 6) |
| March 28 | Mechanism of catecholamine action, receptors and receptor subtypes. (Chapter 6 and 3) |
| April 2 | Steroidogenic tissues, steroid hormones biochemistry. (Chapter 2) |
| April 4 | Second examination (subjects including March 28th lecture) |
| April 9 | Adrenal cortex: Structure and function (Chapter 6) |
| April 11 | Mechanism of action of adrenocortical hormones (Chapter 6) |
| April 16 | Reproductive system / Male reproductive endocrinology(Chapter 7) |
| April 18 | Testis: Hormones and their actions, (Chapter 7) |
| April 23 | Female reproductive endocrinology (Chapter 7) |
| April 25 | Ovary: Organization, structure and hormones (Chapter 7) |
| April 30 | Actions of ovarian hormones, role in reproduction (Chapter 7) |
| May 2 | Immune-Endocrine interactions, cytokines and hormones. |
| May 10 at 1:30 PM | Final Examination |
