Phone: 612-626-4509
Email: voytas@umn.edu
Office: Room 5-112 MCB
Campus Mail:
Genetics, Cell Biology/Dev
Room 6-160 JacH 1217
321 Church St SE
Minneapolis, MN 55455
The Voytas lab publishes a paper online in May 2010 in the Proceedings of the National Academy of Sciences USA. The paper describes the use of zinc finger nucleases (ZFNs) to create targeted mutations in Arabidopsis. As many as two-thirds of transgenic Arabidopsis plants expressing ZFNs segregate mutations in the next generation. Many plants go from homozygous wild type to homozygous mutant in a single generation. The use of ZFNs provides a new tool for genetic analyses in this important plant model.
The Voytas lab publishes a paper online at Nature on April 29, 2009 describing the first use of zinc finger nucleases to stimulate homologous recombination at endogenous plant genes. The study, a joint effort of the Voytas and Joung labs, uses zinc finger nucleases to introduce amino acid sequence changes in a plant gene that confer herbicide resistance. Targeted gene modification of plant genes has been a long-standing goal in plant biology, which is now realized through the use of zinc finger nucleases. This opens up new opportunities to dissect plant gene function and develop new plants with valuable traits.
