Reprints

57: Kerr, Neuhauser, Bohannan & Dean. 2005. (pdf)
Local migration promotes competitive restraint in a host-pathogen 'tragedy of the commons'.
Nature In Press.

56: Merlo, Ferguson, Sadowsky & Dean. 2005. (pdf)
Selection and polymorphism at the argR locus of Escherichia coli.
Gene In Press.

55: Lunzer, Miller, Felsheim & Dean. 2005. (pdf)(SupportingOnlineMaterial.pdf)(Perspectives.pdf)
The biochemical architecture of an ancient adaptive landscape.
Science 310:499-501.

54: Suiter & Dean. 2005. (pdf)
Selection in a seasonal environment: the impact of phenotypic lag on Darwinian fitness.
J Mol Evol 61:153-170.

53: Zhu, Golding & Dean. 2005. (pdf)(SupportingOnlineMaterial.pdf)
The selective cause of an ancient adaptation.
Science 307:1279-1282.

52: Dean. 2005. (pdf)
Protecting haploid polymorphisms in temporally variable environments.
Genetics 169:1147-1156.

51: Zhang, Dean, Brunet & Long. 2004. (pdf)
Evolving protein functional diversity in new genes of Drosophila.
Proc Natl Acad Sci USA 101:16246-16250.

50: Zhong, Kodursky, Dykhuizen & Dean. 2004. (pdf) (SupportingTable3.html)(SupportingTable4.html)
Evolutionary genomics of ecological specialization.
Proc Natl Acad Sci USA 101:11719-11724.

49: Dykhuizen & Dean. 2004. (pdf)
Evolution of specialists in an experimental microcosm.
Genetics 167:2015-2026.

48: Zhong & Dean. 2004. (pdf)
Locating insertion sequences in microbial genomes using vectorette PCR.
BMC Microbiol 4:26.

47: Ma, Kotaria, Mayor, Eriks, Dean, Walters & Kaplan. 2004. (pdf)
The mitochondrial citrate transport protein: probing the secondary structure of transmembrane domain III, identification of residues that likely comprise a portion of the citrate transport pathway, and development of a model for the putative TMDIII-TMDIII' Interface.
J Biol Chem 279:1533-1540.

46: Suiter, Bänziger & Dean. 2003. (pdf)
Fitness consequences of a regulatory polymorphism in a seasonal environment.
Proc Natl Acad Sci USA 100:12782-12786.

45: Tahoe, Dean & Curtsinger. 2002. (pdf)
Nucleotide variations in the lxd region between long-lived and normal-lived control lines of Drosophila melanogaster: lxd characterization.
Gene 197:221-228.

44: Dean, Neuhauser, Grenier & Golding. 2002. (pdf)
The pattern of amino acid replacements in a/b-barrels.
Mol Biol Evol 19:1846-1864.

43: Lunzer, Natarajan, Dykhuizen & Dean. 2002. (pdf)
Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac.
Genetics 162:485-499.

42: Singh, Miller, Dean, Banaszak & LaPorte. 2002. (pdf)
Bacillus subtilis isocitrate dehydrogenase: a substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase.
J Biol Chem 277:7567-7573.

41: Bishop, Dean & Mitchell-Olds. 2000. (pdf)
Rapid adaptive evolution in the active site of plant class I chitinases.
Proc Natl Acad Sci USA 97:5322-5327.

40: Kaplan, Mayor, Brauer, Kotaria, Walters & Dean. 2000. (pdf)
Yeast mitochondrial transport protein: probing the secondary structure of transmembrane domain IV and identification of residues that likely comprise a portion of the citrate transport pathway.
J Biol Chem 275:12009-12016.

39: Miller, Chen, Karshina, Dean & LaPorte. 2000. (pdf)
Locations of the regulatory sites for isocitrate dehydrogenase kinase/phosphatase.
J Biol Chem 275:833-839.

38: Dean & Golding. 2000. (pdf)
Enzyme evolution explained (sort of).
In: Pacific Symposium on Bioinformatics 2000, pp 6-17.
Altman, Dunker, Hunter, Lauderdale & Klein, Eds. World Scientific, Singapore.

37: Watt & Dean. 2000. (pdf)
Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes.
Annu Rev Genet 34:593-622.

36: Dean & Dean. 1999. (pdf)
Carbocations in the synthesis of prostaglandins by the cyclooxygenase of PGH synthase? A radical departure!
Protein Science 8:1087-1098.

35: Golding & Dean. 1998. (pdf)
The structural basis of molecular adaptation.
Mol Biol Evol 15:355-369.

34: Dean. 1998. (pdf)
The molecular anatomy of an ancient adaptive event.
American Scientist 86:26-37.

33: Chen, Greer & Dean. 1997. (pdf)
Structural constraints in protein engineering: The coenzyme specificity of Escherichia coli isocitrate dehydrogenase.
Eur J Biochem 250:578-588.

32: Redfield, Schrag & Dean. 1997. (pdf)
The Evolution of bacterial transformation: sex with poor relations.
Genetics 146:27-38.

31: Chen Greer & Dean. 1997. (pdf)
Engineering secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase.
In: Techniques in Protein Chemistry VIII, pp 809-816.
Marshak, Ed. Academic Press, San Deigo.

30: Dean & Golding. 1997. (pdf)
Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase.
Proc Natl Acad Sci USA 94:3104-3109.

29: Chen, Greer & Dean. 1996. (pdf)
Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase.
Proc Natl Acad Sci USA 93:12171-12176.

28: Stoddard, Dean & Bash. 1996. (pdf)
Combining Laue diffraction and molecular dynamics to study enzyme intermediates: formation of a Michaelis complex.
Nat Struct Biol 3:590-595.

27: Hurley, Chen & Dean. 1996. (pdf)
Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP⁺ to NAD⁺ specificity reversal mutant.
Biochemistry 35:5670-5678.

26: Dean, Shiau & Koshland. 1996. (pdf)
The determinants of performance in the isocitrate dehydrogenase of Escherichia coli.
Protein Science 5:341-347.

25: Chen, Grobelar, Hurley & Dean. 1996. (pdf)
Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Science 5:287-295.

24: Chen, Greer & Dean. 1995. (pdf)
A highly active decarboxylating dehydrogenase with rationally inverted coenzyme specificity.
Proc Natl Acad Sci USA 92:11666-11670.

23: Dean & Dvorak. 1995. (pdf)
The role of glutamate 87 in the kinetic mechanism of Thermus thermophilus isopropylmalate dehydrogenase.
Protein Science 4:2156-2167.

22: Dean. 1995. (pdf)
A molecular investigation of genotype by environment interactions.
Genetics 139:19-33.

21: Hurley & Dean. 1994. (pdf)
Structure of 3-isopropylmalate dehydrogenase in complex with NAD⁺: ligand-induced loop closing and mechanism for cofactor specificity.
Structure 2:1007-1016.

20: Dean. 1994. (pdf)
Fitness, flux and phantoms in temporally variable environments.
Genetics 136:1481-1495.

19: Dykhuizen & Dean. 1994. (pdf)
Predicted fitness changes along an environmental gradient.
Evol Ecol 8:1-18.

18: Stoddard, Dean & Koshland. 1993. (pdf)
The structure of isocitrate dehydrogenase with isocitrate, NADP, and calcium at 2.5Å resolution: a pseudo-Michaelis ternary complex.
Biochemistry 32:9310-9316.

17: Dean & Koshland. 1993. (pdf)
The kinetic mechanism of Escherichia coli isocitrate dehydrogenase.
Biochemistry 32:9302-9309.

16: Hurley, Dean, Koshland & Stroud. 1991. (pdf)
Catalytic mechanism of NADP⁺-dependent isocitrate dehydrogenase: structure of a magnesium-isocitrate complex.
Biochemistry 30:8671-8678.

15: Dean & Koshland. 1990. (pdf)
Electrostatic & steric contributions to regulation at the active site of isocitrate dehydrogenase.
Science 249:1044-1046.

14: Hurley, Dean, Stohl, Koshland & Stroud. 1990. (pdf)
Regulation of an enzyme by phosphorylation at the active site.
Science 249:1012-1016.

13: Hurley, Dean, Thorsness, Koshland & Stroud. 1990. (pdf)
Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.
J Biol Chem 265:3599-3602.

12: Dean. 1990. (pdf)
Molecular adaptation in the lactose operon.
In: Control of Metabolic Processes, pp 389-398.
A Cornish-Bowden, Ed. Plenum, New York.

11: Dykhuizen & Dean. 1990. (pdf)
Enzyme activity and fitness: Evolution in solution.
Trends Ecol Evol 5:257-262.

10: Dean, Lee & Koshland. 1989. (pdf)
Phosphorylation inactivates Escherichia coli isocitrate dehydrogenase by preventing isocitrate binding.
J Biol Chem 264:20482-20486.

9: Dean. 1989. (pdf)
Selection and neutrality in lactose operons of Escherichia coli.
Genetics 123:441-454.

8: Dean, Dykhuizen & Hartl. 1988. (pdf)
Theories of metabolic control in quantitative genetics.
In: Proceedings of The Second International Symposium on Quantitative Genetics, pp 536-548.
Weir, Eisen, Goodman & Namkoong, Eds. Sinauer Associates Inc, Sunderland, Mass.

7: Dean, Dykhuizen & Hartl. 1988. (pdf)
Fitness effects of new amino acid substitutions in the b-galactosidase of Escherichia coli.
Mol Biol Evol 5:469-485.

6: Dykhuizen, Dean & Hartl. 1987. (pdf)
Metabolic flux and fitness.
Genetics 114:25-31.

5: Hartl, Dean & Dykhuizen. 1986. (pdf)
The molecular biology of natural selection: reply to Burton and Place.
Genetics 114:1037-1039.

4: Dean, Dykhuizen & Hartl. 1986. (pdf)
Fitness as a function of b-galactosidase activity in Escherichia coli.
Genet Res 48:1-8.

3: Hartl, Dykhuizen & Dean. 1985. (pdf)
Limits of adaptation: the evolution of selective neutrality.
Genetics 111:655-674.

2: Dean. 1985. (pdf)
The dynamics of microbial commensalisms and mutualisms.
In: The Biology of Mutualism, pp 270-304.
Boucher, Ed. Croom Helm, London.

1: Dean. 1983. (pdf)
A simple model of mutualism.
Am Nat 121:409-417.