William Oetting, PhD

Research Techniques:

STRP genotyping; SNP analysis; DNA sequencing

Research Interests:

Dr. Oetting's research focuses on the genetic analysis of common diseases. His major research is identifying genetic variants associated with adverse outcomes in solid organ transplantation. This work is includes using a high density SNP chip for association studies. My research in transplantation also includes proteomic analysis of urine to identify biomarkers associated with different clinical outcomes.

Dr. Oetting is also interested in determining variants associated with susceptibility to asthma. The lab has identified several loci associated with asthma in families and we are currently mapping theses asthma susceptibility genes.

Dr. Oetting is the director of the DNA analysis core facility of the General Clinical Research Center.

Selected Publications:

Akkina S, Zhang Y, Nelsestuen G, Oetting WS, Ibrahim HN. 2009. Temporal stability of the urinary proteome after kidney transplant: more sensitive than protein composition?  Journal of Proteome Research 8:94-103. [PMID: 19012427] [PMC2722382]

Oetting WS, Pietsch, J, Brott, MJ, Savage S, Fryer JP, Summers CG, King, RA. 2009. The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism.  American Journal of Medical Genetics  149A:466-469. [PMID: 19208379]

Zhang Y, Oetting WS, Harvey SB, Stone MD, Monkkonen T, Matas AJ, Nelsestuen GL. 2009 Urinary protein profiles: diagnosis and prognosis of kidney transplant outcomes.  Transplantation  87:1807-1813. [PMID: 19543057] Communicating author

He H, Oetting WS, Brott MJ and Basu S. 2009. Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study.  BMC Medical Genetics 10:127. [PMID: 19961594] [PMC2800840]
He H, Oetting WS, Brott MJ and Basu S. 2010. Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case control study.  Human Heredity69:60-70. [PMID: 19797910]

Israni A, Leduc R, Holmes J, Jacobson PA, Guan W, Schladt D, Chen J, Matas AJ, Oetting WS. 2010. Single nucleotide polymorphisms, acute rejection and severity of tubulitis in kidney transplantation, accounting for center-to-center variation.  Transplantation90:1401-1408. [PMID: 21085059]

Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, Lamba V, Mannon RB, Julian BA, Israni A for the DeKAF investigators. 2011. Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation.  Transplantation 91:309-316. [PMID: 21107304]

Jacobson PA, Oetting WS, Brearley AM, Leduc R, Guan W, Schladt D, Matas AJ, Lamba V, Julian BA, Mannon RB, Israni A for DeKAF investigators. 2011. Novel polymorphisms associated with tacrolimus trough concentrations: Results from a multicenter kidney transplant consortium.  Transplantation 91:300-308 [PMID: 21206424]. Issue Highlight

Sarafoglou K, Lorentz CP, Otten N, Oetting WS, Grebe SKG. 2011. Molecular testing in congenital adrenal hyperplasia due to 21a-hydroxylase deficiency in the era of newborn screening.  Clinical Genetics  (Epub ahead of print) [PMID: 21534945].

Passey C, Birnbaum A, Brundage RC, Oetting WS, Israni AK, Jacobson PA. 2011. Dosing equation for tacrolimus using genetic variants and clinical factors.  British Journal of Clinical Pharmacology 72:948-957 [PMID: 21671989].

Oetting WS. 2011. Albinism: Genetics, Encyclopedia of Life Sciences,John Wiley & Sons, Ltd. Version 2.

Basu S, Pan W, Oetting WS. 2011. A dimension reduction approach for modeling multi-locus interaction in case-control studies.  Human Heredity 71:234-245 [PMID: 21734407].

Dalgleish R, Oetting WS, Auerbach AD, Beckmann JS, Cambon-Thomsen A, Devereau A, Greenblatt MS, Patrinos GP, Taylor GR, Vihinen M, Brookes AJ. 2011, Clarity and claims in variation/mutation databasing.  Nature Biotechnology 29:790-792. [PMID: 21904316]

Oetting WS, Zhu Y, Brott MJ, Matas AJ, Cordner GK, Pan W. 2011. Validation of genetic variants MTHFR, IL10 and TGFB1 with early acute rejection in kidney allograft transplantation.  Clinical Transplantation (Epub ahead of print) [PMID: 21919968]

Basu S, Pan W, Shen X, Oetting WS. 2011. Multi-locus association testing with penalized regression.  Genetic Epidemiology (Epub ahead of print) [PMID: 21922539].

Oetting WS, Schladt DP, Leduc R, Jacobson PA, Guan W, Matas AJ, Israni A. 2011. Validation of single nucleotide polymorphisms (SNPs) associated with acute rejection in kidney transplant recipients using a large multi-center cohort.  Transplant International 24:1231-1238 [PMID: 21955043].

To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed
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