Daniel Voytas, PhD

Research Techniques:

Use of zinc finger nucleases for genome engineering

Research Interests:

Plant genome engineering through homologous recombination;
Retrotransposable elements and genome organization

Selected Publications:

Townsend, J.A., Wright, D.A., Winfrey, R.J., Fu, F., Maeder, M.L., Joung, J.K. and Voytas, D.F. (2009). High frequency modification of endogenous plant genes using engineered zinc finger nucleases.  Nature, 459:442-445.

Sander, J.D., Zaback, P., Joung, J.K., Voytas, D.F., Dobbs, D. (2008) An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins. Nucleic Acids Res. 37:509-515.

Fu, F, Sander, JD, Maeder, ML, Thibodeau-Beganny, S, Joung, JK, Dobbs, D, Miller, L, Voytas, D. (2009). Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc finger proteins and engineered zinc finger arrays. Nucleic Acids Res. 37:D279-283.

Maeder, ML, Thibodeau-Beganny, S, Osiak, A, Wright, DA, Anthony, RM, Eichtinger, M, Jiang, T, Foley, JE Winfrey, RJ, Townsend, JA, Unger-Wallace, E, Sander, JD, Muller-Lerch, F, Fu, F, Pearlberg, J, Gobel, C, Dassie, JP, Pruett-Miller, SM, Porteus, MH. Sgroi, DC, Lafrate, AJ, Dobbs, D, McCray, PB, Cathomen, T, Voytas, DF, Joung, JK. (2008). Rapid 'open-source' engineering of customized zinc finger nucleases for highly efficient gene modification. Mol. Cell, 31:294-301.

Ramirez, CL, Foley, JE, Wright, DA, Müller-Lerch, F, Rahman, SH, Cornu, TI, Winfrey, RJ, Sander, JD, Fu, F, Townsend, JA, Cathomen, T, Voytas, DF, Joung, JK. (2008). Unexpected failure rates for modular assembly of engineered zinc fingers.  Nature Methods 5:374-375.

Brady, TL, PG Fuerst, RA Dick, C Schmidt and DF Voytas. Retrotransposon target site selection by imitation of a cellular protein.  Mol. Cell. Biol. 2008. Mol. Cell. Biol. 28:1230-1239.

Gao, X, H Yi, H Ebina, H Levin and DF Voytas.  Chromodomains direct integration of retrotransposons to heterochromatin. Genome Res. 2008. Genome Res. 18:359-369.

Dai J, Xie W, Brady TL, Voytas DF. Phosphorylation regulates integration of the yeast Ty5 retrotransposon into heterochromatin. Mol. Cell. 27:289-299.

Wright DA, Thibodeau-Beganny S, Sander J, Winfrey RJ, Hirsh AS, Eichtinger,M, Fu F, Porteus MH, Dobbs D, Voytas DF and Joung JK.  Standardized reagents and protocols for engineering zinc finger nucleases by modular design. Nature Protocols.  2006 1:1637-1652.

 

To view these and other publications visit http://www.ncbi.nlm.nih.gov/PubMed
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