Chemical and Structural Biology Division
FACULTY AND RESEARCH INTERESTS
Molecular mechanisms of DNA rearrangement/recombination reactions
Multinuclear magnetic resonance techniques; metalloproteins/metal homeostasis; Alzheimer's Disease.
Oxygenase mechanisms, metalloproteins, magnetic resonance techniques, kinetics.
Protein structure; RNA structure; Protein-RNA, DNA interaction; Enzyme kinetics.
Cell adhesion; protein-protein/carbohydrate interactions.
Protein engineering; structural biology; x-ray crystallography; molecular biology.
Molecular dynamics in muscle.
Structure and dynamics of membrane embedded enzymes.
Targeted protein degradation; Protein quality control; NMR spectroscopy.
Structural enzymology: Metal ions & organic co-factors; Human disease: cardiovascular, Alzheimers.
Biological networks that coordinate metabolism and growth.
Diabetes, metabolite sensing and signaling, metabolic enzyme regulation.
Joint Members - From Other Departments
Que, Jr., Lawrence
Active site structures and mechanisms of nonheme iron enzymes; trapping of reactive intermediates, design and synthesis of functional metalloenzyme models and chiral oxidation catalysts; artificial DNA hydolysis agents.