Calander Home 2001-2002 2002-2003 February 11 - Brian Brazeau Hydrogen Tunnelling in Enzyme Catalyzed Reactions Date: 2/11/02 Prof. Kara L. Bren - Dept. of Chemistry, University of Rochester will present: Dynamics of Thermophilic and Mesophilic Cytochromes c: How are Flexibility and Stability Related? Brian Brazeau of the Lipscomb Lab, will present a talk on: Hydrogen Tunnelling in Enzyme Catalyzed Reactions Hydrogen transfer is of great importance in biology, ranging from proton transfer to C-H bond homolysis. There is increasing evidence for quantum effects on enzyme-catalyzed hydrogen transfer, suggesting that transition state theory may not completely describe the nature of enzyme catalysis. This talk with discuss quantum effects and the significance of protein motions in enzyme-catalyzed hydrogen transfer reactions. Details will be drawn from several references. Two key references are: Kohen, A. and Klinman J.P., Chemistry and Biology July 1999, 6, R191-198. Scrutton, N.S., Basran, J., and Sutcliffe, M.J., Eur. J.Biochem., 1999, 264, 666-671.