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Dioxygenases |
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| The degradation of aromatic compounds in the environment converge on a small number of
catechol derivatives. These key aromatic
intermediates are cleaved into aromatic compounds by dioxygenases. Dioxygenases can be classified by the location of their cleavage site.
Intradiol dioxygenases use Fe(III) to cleave between the vicinal hydroxyls. Extradiol dioxygenases cleave outside the hydroxyls. When R is not a hydrogen, the two nonequivalent sites lead to proximal and distal cleavage. Proximal extradiol dioxygenases use Fe(II) or Mn(II) to cleave the aromatic ring. |
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