Research Interests   mRNA Stability; Plant-Pathogen Interactions; Gene Expression

One of my primary research interests focuses on the regulation of gene expression in cells in response to stress such as nutrient deprivation, culture density, osmotic stress, heat shock, and mechanical stress. Our approaches include studying the regulation of transcription, mRNA degradation and protein synthesis in cells grown under a variety of culture conditions. In addition, we are studying the physiology of cells immobilized in latex and the development of these biofilms as biocatalysts and biosensors.

In another research program, my laboratory is studying the interaction between pathogenic streptomycetes and their host plants. Streptomyces scabies causes scab disease on a variety of underground vegetables. In this system, we are characterizing phytotoxins produced by the pathogen that are involved in eliciting lesion formation on the plant, elucidating the biosynthetic pathway of the phytotoxin, and studying the mechanism of biological control of this disease.

Schottel, J.L., Orwin, .M., Anderson, C.R. and Flickinger, M.C. 2008. Spatial expression of a mercury-inducible green fluorescent protein within a nanoporus latex-based biosensor coating. J. Ind. Microbiol. Biotechnol. 35(4):283-90.

Flickinger, M.C., Schottel, J.L., Bond, D.R., Aksoan, A. and Scriven, L.E. 2007. Painting and printing lliving bacteria: engineering nanoporus biocatalytic coatings to preserve microbial viability and intensify reactivity. Biotechnol. Prog. 23(1):2-17.

Schottel, J.L., K. Shimizu, and L.L. Kinkel. 2001. Relationships of in vitro pathogen inhibition and soil colonization to potato scab biocontrol by antagonistic Streptomyces spp. Biol. Control 20:102-112.

Neeno-Eckwall, E.C., L.L. Kinkel, and J.L. Schottel. 2001. Competition and antibiosis in the biological control of potato scab. Can. J. Microbiol. 47:332-340.

Lyngberg, O.K., D.J. Stemke, J.L. Schottel, and M.C. Flickinger. (1999) A single-use luciferase-based mercury biosensor using Escherichia coli HB101 immobilized in a latex copolymer film. J. Ind. Microbiol. Biotechnol. 23:668-676.

Thiagarajan, V.S., Z. Huang, L.E. Scriven, J.L. Schottel, and M.C. Flickinger. (1999) Microstructure of a biocatalytic latex coating containing viable Escherichia coli cells. J. Coll. Inter. Sci.æ 215:244-257.

Lyngberg, O.K., V. Thiagarajan, D.J. Stemke, J.L. Schottel, L.E. Scriven and M.C. Flickinger.æ(1999) A patch coating method for preparing biocatalytic films of Escherichia coli. Biotechnol. Bioeng. 62:44-55.

Neeno-Eckwall, E.C. and J.L. Schottel. (1999) Occurrence of antibiotic resistance in the biological control of potato scab disease.æ Biol. Control 16:199-208.

Kinkel, L.L., Bowers, J.H., Shimizu, K., Neeno-Eckwall, E.C. and Schottel, J.L. (1998) Quantitative Relationships Among Thaxtomin A Production, Potato Scab Severity, and Fatty Acid Composition in Streptomyces. Can. J. Microbiol. 44:768-776.

Kuzj, A.E.S., P.S. Medberry, and J.L. Schottel. (1998) Stationary phase, amino acid limitation and recovery from stationary phase modulate the stability and translation of chloramphenicol acetyltransferase mRNA and total mRNA in Escherichia coli. Microbiol. 144:739-750.