Research Interests   Gene structure and regulation

Research in my laboratory is concerned with the genes for the thrombospondin (TSP) proteins and the metaxin (MTX) proteins. The thrombospondins (TSP1-5) are extracellular proteins with roles in processes including angiogenesis, tumor growth, and skeletal development. The metaxins (MTX1 & 2) are mitochondrial membrane proteins that function in protein transport. Recent projects have involved sequencing cDNAs for thrombospondins 3 and 4 in zebrafish and a cDNA for a thrombospondin homologue in Drosophila . Another research focus has been to sequence cDNAs for a new metaxin protein (MTX3), not previously described, in zebrafish and Xenopus.

Adolph, K.W. (2005). Characterization of the cDNA and amino acid sequences of Xenopus metaxin 3, and relationship to Xenopus metaxins 1 and 2. DNA Sequence, in press.

Adolph, K.W. (2004). The zebrafish metaxin 3 gene ( mtx3 ): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Gene 330 , 67-73 (online) DNA Sequence, in press.

Adolph, K.W. (2002). The zebrafish thrombospondin 3 and 4 genes ( thbs3 and thbs4 ): cDNA and protein structure. DNA Sequence 13 , 277-285. DNA Sequence, in press.

Adolph, K.W. (2001). A thrombospondin homologue in Drosophila melanogaster: cDNA and protein structure. Gene 269 , 177-184. (online)

Adolph, K.W., and Bornstein, P. (1999). The human thrombospondin 3 gene: Analysis of transcription initiation and an alternatively spliced transcript. Mol. Cell Biol. Res. Commun. 2 , 47-52.